RFR-CABG stands for Resting full-cycle Flow Ratio (RFR) versus Angiography to guide Revascularization Strategy in Patients Undergoing Coronary Artery By-pass Grafting (CABG)


RFR is a measurement performed to evaluate the hemodynamic severity of coronary stenosis. Differently from Fractional Flow Reserve (FFR) which is a measurement performed in maximal hyperemia, the RFR is a measurement that is performed in rest and therfore may predict better than FFR the baseline equilibriums that could lead to graft failure, while it has similar capacity to identify hemodynamically significant stenosis as FFR.

The main objectives are:

  • To compare RFR guided versus angiography guided CABG revascularization
  • To define the best cut-off value that predicts graft occlusion for RFR

Primary endpoint is a composite of Death, Myocardial Infarction (MI), Clinically-Driven Target Vessel Revascularization (CD-TVR), Stroke and Graft Dysfunction at 3 months post CABG.

The RFR-CABG trial is an international prospective randomized multicenter superiority trial designed to enroll 500 patients in Belgium, Slovakia and Poland.

Clinical investigator

Name: Prof. Elvin Kedhi MD, PhD (interventional cardiologist)
Location: Hopital Erasme, Brussels (Belgium)

Clinical trial information