Early BAMI stands for: Early Beta blocker Administration before reperfusion in patients with ST-Elevation Myocardial Infarction who are planned to undergo primary PCI



The trial evaluated the beneficial effects of early administration of 5 mg intravenous Metoprolol or placebo before reperfusion in the ambulance or emergency room in patients with ST elevation myocardial infarction. The physician-initiated, prospective, multicenter, randomized, double-blind, placebo controlled trial has now completed enrolment and follow-up till two years of all 684 patients in 14 centers in The Netherlands and Spain.

The primary endpoint is infarct size as measured by cardiac MRI 1 month post-MI. Patients have been randomized in a 1:1 fashion to receive either Metoprolol or placebo.

Clinical investigators

Principal investigator is Vincent Roolvink MD of the Isala hospital, Zwolle, The Netherlands. Coordinating investigator of Spain is Borja Ibañez MD, PhD of CNIC and Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. Patients were mainly included in the acute phase by ambulance services:

The Netherlands:

Spain: SUMMA 112

Clinical trial information


Main publications


Presentation at ACC congress 2016