Each trial starts with the Start-up phase. So how can we help you during this initial stage?

Clinical Trial Services Research QuestionResearch question

The aim of every trial is to answer the Research Question. We advise and support you in formulating the perfect Research Question that will result in a successful trial and noteworthy publications. 

Using the respected PICO method, we’ve defined research questions for hundreds of trials across 25 countries in Europe and Asia. 

It’s the foundation of every trial. Start with a weak one and you won’t build a great trial.

– Sonja Postma, Project manager Diagram Research

Grant submission and Funding

Diagram has noteworthy experience in grant submissions, like Horizon 2020, Hartstichting and ZonMw. For example, the EU-CaRE and EU-CaRE RCT trial are funded by the Horizon 2020 Framework Programme of the European Union and by the government of Switzerland.

Budget and contracting

Trial budget budgets can be prepared by Diagram as well as monitoring of trial budgets during a trial. In addition, contract negotiations with all involved parties (sponsor, investigators, vendors etc.) can be facilitated to unburden the sponsor of the trial.

Project management

The dedicated project management team of CRO Diagram is able to perform the project management for all phases of the trial including the start-up phase. the following tasks can be facilitated:

  • Site selection
  • Site management
  • Trial register submission (e.g. Clinicaltrials.gov or NTR)
  • Coordination study supplies (study medication, devices etc.)
  • Site visits
  • Organisation of start-up meetings

Institutional Review Board and Competent Authority

Coordination of the Institutional Review Board and Competent Authority process can be facilitated by Diagram on national and international level. Each trial is unique resulting in a determination per trial to which committees (central and local) and authorities the trial has to be submitted. Since the requirements differ per country, local guidelines will be followed when starting up a participating hospital.

Trial database